Yes, but you will need to go into the profile customiser module to add the code so one can select "padding" and "margins" By the way, one can use transparency in the boxes background by entering the rgba() code in the colour box instead of using the colour picker. There is a forum topic for adding it to the customiser but I just tell my members to enter the rgba() in the input box.
By the way, by default, all of the boxes on the profile page are designboxfirst; designbox_1.html. So the code affects all boxes at the same time. If you want different boxes to have different codes, then you need to create new designboxes and change the boxes to use the new designboxes. For example, if you wanted the profile comments box to be able to be style differently, copy designbox_1. html to designbox_6.html ( or whatever is free), edit it to use a different CSS class and then add it to the profile customiser.